Scientists have built a better nanoparticle that can more effectively locate and destroy breast tumors.
|Polymer Nanoparticle Shows Ability to Locate and Treat Breast Tumours|
Researchers have developed a fluorescing nanoparticle capable of finding tumours, lighting up upon arrival and being activated with light to generate heat to destroy the cancer cells.
A study in which these nanoparticles – Hybrid Donor-Acceptor Polymer Particles, or H-DAPPs – successfully located and killed breast cancer skills in mice is published in the current issue of the journal ACS Applied Materials and Interfaces. The result may help to overcome the major problem in treating cancer which is identifying the location of small tumours and treating them before they metastasize.
“An unexpected result was how efficiently the nanoparticles localized to the tumours without any targeting agent,” said the study’s lead author, Dr. Nicole Levi-Polyachenko, associate professor of plastic and reconstructive surgery at Wake Forest School of Medicine, part of Wake Forest Baptist. “Achieving high enough levels of H-DAPPs within the tumour to allow it to be seen provides an advantage for knowing exactly where light should be applied to generate heat and kill the cancer cells.”