Rats may have just proven that using nanotechnology in oral surgery may be a painless way to fix a mouth. Scientists have used liposomal nanoparticles to deliver collagenase, which can be used to ‘remodel the fibers connecting to bone in the mouth.’ This procedure means no scalpel, no cutting is needed.
|Nanotechnology could redefine oral surgery|
Scientists recently have turned to nanotechnologies to target therapeutics to specific locations. For example, previous studies have shown some success in using liposomes, which are empty nanoscale vesicles, for drug delivery. Collagenase enzymes could potentially remodel the fibers connecting teeth to bone in the mouth without using a scalpel, but so far, delivering enzymes with liposomes has been challenging. Avi Schroeder and colleagues wanted to develop liposomes that could deliver collagenase enzymes to perform targeted nanosurgery in the mouth.
The team developed liposomal nanoparticles that contained collagenase and performed tests with them in rats. When the liposomes were placed under the gums, the collagenase diffused out of the particles and was activated by calcium naturally found in the mouth. The collagenase weakened the collagen fibers, making it easier to shift the teeth afterward with braces. Compared to conventional surgery, the collagenase treatment helped move the teeth three times faster. All of the rats lost some weight after the surgery, just as humans typically do. But unlike the other rats, the ones treated with collagenase quickly rebounded to their normal healthy weight, which the researchers say suggests they were not in pain.
|Read More at Eurekalert.org|